Glutathione specifications and molecular characteristics
The technical specification for Glutathione, the Glutathione research material supplied by Glutathione Labs: molecular formula C10H17N3O6S, average molecular weight 307.32 g/mol, 3 residues, supplied as a white lyophilized powder. Each item is explained below.
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Specification table
| Product | Glutathione |
|---|---|
| Type | Tripeptide thiol (reduced glutathione, GSH) |
| Molecular formula | C10H17N3O6S |
| Molecular weight | 307.32 g/mol (average) |
| Length | 3 residues |
| Sequence | γ-Glu-Cys-Gly |
| Form | Reduced (GSH), free thiol |
| Linkage | γ-Glutamyl bond (Glu side chain to Cys) |
| CAS number | 70-18-8 |
| Form | White lyophilized powder |
| Vial sizes | 600 mg |
| Purity specification | ≥95% (HPLC-UV) |
| Purity, current lots | 99.37% |
| Identity specification | Confirmed by LC-MS |
| Testing laboratory | Freedom Diagnostics (independent) |
| Storage | Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. |
| Designation | Research use only |
Current lot results against specification
Every current lot meets the release specification. Current lots test at 99.37% by HPLC-UV against a specification of ≥95%, and identity is confirmed by LC-MS on every lot.
Glutathione molecular formula
The molecular formula of Glutathione is C10H17N3O6S.
Glutathione molecular weight
The average molecular weight of Glutathione is 307.32 g/mol. "Average" means it is calculated from natural isotope abundances, which is the value used to predict the ions seen in LC-MS. With this weight, Glutathione is expected at m/z 308.3 with one charge and m/z 154.7 with two charges.
Glutathione sequence
γ-Glu-Cys-Gly
γ-Glu indicates the γ-peptide bond between the glutamate side chain and cysteine.
Structure and modifications
The free thiol makes glutathione sensitive to air oxidation, especially in solution, where it slowly converts to the disulfide GSSG (612.6 g/mol). LC-MS distinguishes the two easily. Keeping the powder sealed and dry limits that conversion.
Physical form
White lyophilized powder, recorded as the appearance on every certificate. Lyophilization (freeze-drying) removes water, which slows most chemical degradation. What lyophilized means.
Purity and identity specifications
Glutathione Labs’ stated release specification is ≥95% HPLC-UV purity with identity confirmed by LC-MS. The current lot, KB9987, reported 99.37%. How purity is measured, or how specifications fit into the quality and supply-chain process.
Analytical and testing methods
HPLC-UV for purity, LC-MS for identity and laboratory quantitation for net content, performed on every lot by Freedom Diagnostics. LAL endotoxin testing (USP <85>) and PCR microbial screening are reported for lots where they were run. Testing and quality control.
Research designation
Glutathione is designated research use only: supplied for laboratory research by qualified personnel. Research use only policy.
Buy Glutathione
600 mg vials. Current lot KB9987 tested at 99.37% purity with identity confirmed by LC-MS. Current purchasing is available through Klow.bio.